I do not hear any sound in The Misadventures of P.B. Winterbottom.
If you are encountering problems that the game failed to produce any sound with a Creative Audigy SE sound card installed under Windows® Vista, you can try to disable all audio enhancements that the driver enabled by default. To disable the enhancements:
1. Open the "Control Panel" and select "Sound".
2. Select the Audio Device (usually "SB Audigy") and click "Properties".
3. Select the "Audio Enhancement" Tab.
4. Select "Disable all Enhancements".
5. Apply changes.