I do not hear any sound in The Misadventures of P.B. Winterbottom.
If you are encountering problems that the game failed to produce any sound with a Creative Audigy SE sound card installed under Windows® Vista, you can try to disable all audio enhancements that the driver enabled by default. To disable the enhancements:
- Open the "Control Panel" and select "Sound".
- Select the Audio Devive (usually "SB Audigy") and click "Properties".
- Sekect the "Audio Enhancement" Tab.
- Select "Disable all Enhancements".
- Apply changes.